Encapsulation of doxorubicin into liposomes by a freeze-thawing method using buffer solution.
نویسندگان
چکیده
منابع مشابه
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Loading of doxorubicin into liposomes by forming Mn2+-drug complexes.
A new procedure for loading doxorubicin into large unilamellar vesicles (LUVs) is characterized. It is shown that doxorubicin can be loaded into LUVs composed of sphingomyelin/cholesterol (55:45 mole/mole) in response to a transmembrane MnSO4 gradient in the absence of a transmembrane pH gradient. Complex formation between doxorubicin and Mn2+ is found to be a driving force for doxorubicin upta...
متن کاملEffect of Freeze-Thawing Process on the Size and Lamellarity of PEG-Lipid Liposomes
The influence of the freeze-thawing process on the size and lamellarity of multilamellar PEG-lipid liposomes prepared from a mixture of egg yolk phosphatidilcholine (EggPC) and distearoyl phosphatidylethanolamine polyethyleneglycol (DSPE-PEG) 2000 was investigated. Trapped volume measurement, quasielastic light scattering (QELS) and freeze-fracture electron microscopy were used to estimate the ...
متن کاملDenaturation of Enzyme Protein by Freeze-Thawing and Freeze-Drying ; I. Freeze-thawing and freeze-drying of myosin and some other muscle proteins
Changes in physico-chemical properties and m enzymatic activities of some muscle proteins by freeze-thawing or freeze-drying were measured for the purpose of clarifying the mechanism of protein denaturation by freeze-thawing and freezedrying. The results showed following: Freeze-thawing unfolded the conformation of the rod-like proteins and decreased their enzymatic activities. The two effects ...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1991
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.39.773